AUCTORES
Globalize your Research
Case Report | DOI: https://doi.org/10.31579/2641-0419/531
1P. L. Shupyk National University of Healthcare of Ukraine, Kyiv
2KNP "Vyshgorod Central District Hospital
3Bogomolets National Medical University of Ukraine, Kyiv
*Corresponding Author: Golyanovskiy OV, P. L. Shupyk National University of Healthcare of Ukraine, Kyiv.
Citation: Golyanovskiy OV, Tymkiv UM, Klyuzko IV, Kononets OP, Voloshyn OA, Dyndar OA, (2025), Modern Approach to the Treatment of Complete Internal Genital Prolapse with Acute Dysfunction of the Pelvic Organs (Case Report), J Clinical Cardiology and Cardiovascular Interventions, 8(16); DOI:10.31579/2641-0419/531
Copyright: © 2025, Golyanovskiy OV. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 17 November 2025 | Accepted: 09 December 2025 | Published: 11 December 2025
Keywords: complete internal genital prolapse; octenidine, pelvic hernia; vaginal hysterectomy;colpoperineorrhaphy
According to recent clinical studies, the prevalence of internal genital prolapse (GP) varies significantly and is within 20-40% in women over 60 years of age. The most significant risk factors for GP are older age of the woman, vaginal delivery of a large fetus, parity, instrumental vaginal delivery, heavy physical labor and obesity.
An algorithm of actions is given in a rare case of complicated complete prolapse of the internal genitals with acute dysfunction of the pelvic organs, severe edema and impaired trophic function of the vaginal mucosa with the help of a modern effective antiseptic, followed by vaginal hysterectomy.
Patient L., 68 years old was hospitalized with the presence of a tumor-like formation protruding beyond the vulvar ring for 2 years, pain in the lower abdomen, urinary retention, defecation, and body temperature up to 38ºC. Under intravenous anesthesia, a reposition of the incarcerated pelvic hernia was performed, a catheter was installed in the bladder; she was clinically and laboratory examined, an ultrasound was performed, and examined by specialized specialists.
For 2 weeks, local therapy was performed with irrigation of the vagina with a modern broad-spectrum antiseptic - octenidine dihydrochloride (Octenisept), and in connection with acute pyelonephritis, she received antibacterial therapy with uroseptics. Against the background of the treatment, edema and trophic changes of the vaginal mucosa disappeared, vaginal biocenosis and body temperature normalized, which we primarily associated with the use of Octenisept and pyelonephritis therapy. This created conditions for surgical correction of complete GP according to our method using modern energies (monopolar radio-wave scalpel and argon-plasma coagulation of tissues). A total vaginal hysterectomy with uterine appendages was performed. The postoperative period was without complications. Postoperative tissue repair was per primam.
The case of complete internal GP with pelvic hernia incarceration and pelvic organ dysfunction was successfully have been treated thanks to the correctly selected two-stage therapy with initial hernia reduction, local Octenisept therapy with subsequent performed vaginal hysterectomy.
The International Urogynecological Association (IUGA) and the International Society for Urinary Incontinence (ICS) define female pelvic organ prolapse as a deviation from normal sensation, structure, or function experienced by a woman regarding the position of her pelvic organs [1].
In the United States, the prevalence of symptomatic pelvic organ prolapse is projected to increase by 46% to 4.9 million women by 2050. Thus, pelvic organ prolapse is a significant public health problem that will continue to increase as the population ages in developed countries [2, 3].
The main risk factors for internal GP are: older age, pregnancy and vaginal delivery, high parity and obesity, as well as early age at first delivery, delivery using obstetric forceps, prolonged second stage of labor, heavy physical labor, chronic constipation, and delivery of a large fetus [4, 5, 6, 7].
Impaired microcirculation of the pelvic floor tissues, loss of capillary communication between the anterior wall of the uterus and the bladder, impaired venous outflow and pelvic architectonics, insufficient blood supply to the perineum, hypoestrogenism, dystrophy or atrophy of the vaginal epithelium are all factors that contribute to the development of internal GP [8 -11]. Levator ani muscle (LAM) avulsion, associated with weakness of the pelvic floor muscles, increases the risk of GP and the risk of failure to retain a vaginal ring pessary [12].
The wide range of symptoms commonly associated with internal GP includes: a feeling of vaginal fullness, chronic pelvic and low back pain, painful intercourse (dyspareunia), difficulty urinating and constipation or, conversely, urinary and fecal incontinence [13]. Most women experience internal GP symptoms when the anterior margin reaches 0.5 cm distal to the vulvar ring [14]. Sometimes, the low-lying cervix can become irritated by repeated exteriorization and cause abnormal vaginal bleeding [3]. Obstructive defecation symptoms, i.e., straining during defecation, incomplete bowel emptying, are associated with posterior prolapse, particularly rectocele and rectal intussusception. Rectocele may also contribute to fecal incontinence, although this condition is clearly multifactorial [3].
Symptoms of obstructive urination may occur with anterior, apical, and posterior vaginal prolapse due to urethral kinking or external urethral compression [3]. Internal GP can also lead to a well-recognized complication, such as hydronephrosis, which can be defined as dilatation of the renal pelvis and calyces due to impaired urine outflow [15]. One systematic review estimated the prevalence of hydronephrosis in women with internal GP to be between 3.5% and 30.6% [16].
All of these symptoms significantly impair a woman’s quality of life, including making it difficult to perform household tasks that require physical exertion, affecting the psychological perception of one’s body, and causing sexual dysfunction [17, 18, 19]. Women report negative external changes to their bodies, feelings of loss of social significance, irritability, depression, anxiety, and sadness [13, 19, 20, 21].
The POP-Q classification of GP is recommended by major international urogynecological health organizations, including the American Urogynecological Society, the Society of Gynecological Surgeons, and the International Society for Urinary Incontinence [14]. Using six defined measurements of anterior, posterior, and apical support, measured relative to the hymen, this system provides an objective standardized method for grading GP from 0 to IV. Stage IV is complete prolapse of the uterus and adjacent pelvic organs, considered a pelvic hernia. The most distal part of the prolapse protrudes more than 1 cm from the hymen, accompanied, in most cases, by cystocele and rectocele [22].
Compared with transvaginal ultrasound imaging, translabial/transperineal access allows assessment of the functional anatomy of the pelvic floor during manipulations such as the Valsalva maneuver. One of the main applications of translabial ultrasound imaging is the quantitative assessment of GP. Imaging complements the clinical examination to determine the nature and severity of the condition [23].
There is no single approach to the treatment of pelvic organ prolapse. The most optimal treatment for pelvic organ prolapse is selected taking into account the degree of prolapse, the presence of complications, the patient's age and other factors. There are several methods of treating prolapse: mechanical, conservative, surgical [6]. The use of a pessary has a positive effect on the quality of life, sexual function and body appearance, and also contributes to a significant reduction in the symptoms of pelvic organ prolapse, in addition, it is an effective treatment strategy for women who have refused surgical intervention or have contraindications [8]. However, despite their effectiveness, vaginal pessaries demonstrate the appearance of such complications as vaginal discharge, bleeding, chafing and unpleasant odor. Therefore, surgical treatment is indicated for patients with stage III and IV pelvic organ prolapse [24].
If indicated, surgery can be performed transvaginally, laparoscopically, or open, using either the patient’s own tissue or mesh endoprostheses [20, 25, 26]. Regarding the use of synthetic mesh materials during vaginal surgery, it should be noted that they can complicate the postoperative period due to frequent inflammation, rejection of the artificial material, and subsequent recurrence of GP in 8–10% of patients, and also cause stress urinary incontinence after surgery [4, 5, 7, 14].
For many decades, vaginal hysterectomy was a routine procedure in many gynecological departments. However, with the introduction of endoscopy and robotic surgery in recent years, vaginal hysterectomy, especially with autologous reconstructive surgery, has lost much of its priority. A significant reduction in abdominal hysterectomy is certainly desirable, but a reduction in vaginal hysterectomy is not justified in most cases.
A clinical case of complete internal GP complicated by pelvic hernia incarceration with the development of inflammatory-trophic changes in the cervix and vaginal walls is presented, with followed by two-stage therapy of the pelvic hernia, local therapy with Octenisept, and performing vaginal hysterectomy with uterine appendages using our modified ten-step method of pelvic floor reconstruction with autologous tissues (M. Stark et al. - 2022) [27].
Patient L., 68 years old, was hospitalized to the gynecological department of the Vyshgorod Central District Hospital (hereinafter VCDH) with complaints of a tumor-like formation protruding beyond the vulvar ring, the presence of which she has noted for 2 years. She has noted a deterioration in her general condition with problems with urination and defecation in the last 3 days, as well as aching pain in the lower back, lower abdomen and periodic increase in body temperature to 38ºC.
According to the anamnesis - 3 pregnancies, two of which ended in medical abortions, one - in physiological childbirth with a large fetus (m- 4100.0 g) without complications. Menopause - 20 years. Somatic anamnesis is not burdened.
The general condition of the patient at the time of hospitalization was moderate, which was associated with severe pain in the perineum, acute urinary retention, difficulties with walking and an increase in body temperature to 38.0ºС. Blood pressure (BP) - 140/80 mm Hg, pulse (Ps) - 98 beats / min. Visible mucous membranes are clean, pale pink. The abdomen is soft, painless. Pasternacki's symptom is weakly positive on both sides.
When examining the external genitalia, a complete GP is visualized with a pinched prolapsed pelvic hernia, which was located outside the vulvar ring in the form of a tumor-like formation measuring 15x15 cm. The mucous membrane of the vagina, prolapse pelvic hernia, with signs of inflammation, edema, and inflammatory-trophic changes (Figure.1).
Figure 1: Complete internal GP. Impingement of a prolapsed pelvic hernia with impaired function of the pelvic organs and trophic changes in the vaginal mucosa.
In the gynecological department, under intravenous anesthesia, a reduction of the incarcerated pelvic hernia was performed, a catheter was inserted into the bladder; she was clinically and laboratory examined, an ultrasound examination was performed, and she was examined by dedicated experts: a urologist, an anesthesiologist, and a therapist. A full clinical and laboratory examination, ultrasound (US) examination of the abdominal cavity and pelvic organs were prescribed.
After examination by a urologist, clinical and laboratory examination, ultrasound, in addition to a prolapsed pelvic hernia, a diagnosis of bilateral hydronephrosis, chronic pyelonephritis in the acute stage was established.
Results of clinical and laboratory studies taken during hospitalization:
- complete blood count: hemoglobin - 111 g/L, erythrocytes - 3.8 × 1012/L, platelets 344 × 109/L, leukocytes - 19.8 × 109/L, erythrocyte sedimentation rate - 55 mm/h.
- general urine analysis: color - light yellow, transparency - slightly cloudy, specific gravity - 1020, protein - 0.33 g/L. Microscopic examination of urine: erythrocytes - 15-20 in the field of view, leukocytes - cover the entire field of view.
- analysis of vaginal flora secretions: leukocytes cover the entire field of view.
- bacteriological examination of vaginal flora: Escherichia coli and Enterobacter spp. 10x106CFU/L
- bacteriological examination of urine: Staphylococcus aureus – 10x107CFU/L
- coagulogram parameters: prothrombin time -14.9 sec., APTT - 29.6 sec., fibrinogen - 5.4 g/L.
- the level of pro-inflammatory cytokines from trophic and wound surfaces of the vagina and cervix was determined – IL-6 and IL-8 by ELISA method – respectively: 397 pg/mL and 1920 pg/mL.
According to the transvaginal US ( unfortunately, US image wasn’t save) the following was found: the body of the uterus is pear-shaped, measuring 47x40x55 mm. The structure of the myometrium is changed: in the area of the uterine fundus, a subserous leiomyomatous node measuring 32x22 mm (FIGO type 6) without blood flow is visualized. The endometrium corresponds to the menopausal period. The cervix is 40x39 mm in size, hypertrophied, the structure is unchanged, the cervical canal is closed. The ovaries are visualized, the dimensions are normal, the structure is afollicular. The vaults are free.
US diagnosis: echo-signs of uterine leiomyoma (FIGO type 6). Involutive changes of the internal genital organs.
Results of the PAP test by liquid cytology method: the presence of atypical squamous epithelial cells was not detected, which allowed to exclude high-grade squamous intraepithelial lesion (ASC-H).
The clinical diagnosis: complete internal GP with acute dysfunction of the pelvic organs. Pelvic hernia with cysto- and rectocele. Trophic changes of the vaginal epithelium of inflammatory genesis. Chronic pyelonephritis in the acute stage.
Given the acute inflammatory process on the background of complete GP with pelvic hernia entrapment and dysfunction of the pelvic organs, significant edema, elevated body temperature of the patient, and exacerbation of chronic pyelonephritis, it was decided to conduct conservative treatment with the appointment of antibacterial, anti-inflammatory local therapy and to ensure conditions for further planned surgical correction of GP.
Conservative local treatment with Octenisept (100 g contains 0.1 g of octenidine dihydrochloride and 2 g of 2-phenoxyethanol) was prescribed [28, 31, 32] - irrigation of the vagina and cervix twice a day, probiotic - Ecobiol (1 capsule orally 2 times a day) for 10 days [35]. Considering that according to the bacteriological examination of the urine, Staphylococcus aureus was detected - 10x107CFU/L, sensitive to ceftazidime (third-generation cephalosporin), 1.0 g x 2 times a day for 7 days was prescribed [36, 37].
For local treatment, we preferred the use of Octenisept, given our clinical experience of the high effectiveness of this antiseptic in the case of nonspecific and specific vaginitis in gynecological practice (especially with resistant forms of E. coli and Enterobacteriaceae - as in our case), compared to other antiseptics, which is also confirmed by the data of previous clinical studies conducted by other authors [28-31]. Furthermore, Octenidine is known for its broad spectrum antimicrobial activity against multidrug-resistant Gram-positive bacteria (such as Staphylococcus aureus, including mupirocin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase (ESBL), vancomycin-resistant Enterococcus (VRE)) and Gram-negative pathogens (e.g. Pseudomonas aeruginosa, Acinetobacter baumanii, Klebsiella pneumoniae), as well as against various (multi)resistant fungal species (e.g. Candida albicans, Candida auris, Nakaseomyces glabratus), even in the presence of unwanted proteins (e.g. blood, mucous secretions, wound exudate) and within a very short exposure time [29-34], which could not be ruled out in our specific case.
After reposition of the incarcerated pelvic hernia and two weeks of conservative treatment of complicated GP, the patient's general condition normalized: no complaints, normal body temperature, normal urination and defecation were restored. In addition, the swelling of the vagina and cervix disappeared, the vaginal mucosa was epithelialized, signs of local inflammation disappeared, and renal function normalized (no signs of pyelonephritis). We associated the rapid local changes in the vaginal mucosa with the pronounced effective antiseptic and wound-healing effect of Octenisept.
Positive clinical changes of therapy were also confirmed by laboratory indicators. Laboratory test data after conservative treatment:
- general blood test: hemoglobin-122 g/L, erythrocytes-4.2×1012/L, platelets 486×109/L, leukocytes – 5.7×109/L, erythrocyte sedimentation rate – 15 mm/h.
- general urine test: color – light yellow, transparency – transparent, specific gravity – 1015, protein – absent, glucose – absent.
- microscopic examination of urine: erythrocytes – 0-1 in the field of view, leukocytes – 2-3 in the field of view.
- analysis of vaginal flora secretions: leukocytes 2-3 in the field of view, lactobacteria are present; the II purity of the vaginal flora was determined.
- the level of pro-inflammatory cytokines from vaginal secretions was determined - the level of IL-6 and IL-8 by ELISA - respectively: 14 pg/mL and 77 pg/mL.
That is, according to laboratory indicators after treatment, there were no inflammatory-trophic changes in the analysis of vaginal discharge, determined levels of IL-6 and IL-8, and inflammatory changes in the kidneys according to urine analysis [38].
After the therapy and complete stabilization of the patient's condition due to complete GP, the issue of planned surgical intervention with vaginal hysterectomy in 10 steps [27] was resolved according to our modification using modern energies: monopolar radio wave scalpel (RW scalpel), argon plasma coagulation (APC) of tissues (Figure. 2). Written consent to the specified scope of surgical treatment was obtained from the patient.
Figure 2: The final stage of total vaginal hysterectomy (step 7) with subsequent ligation of the appendage stumps and uterine ligaments with reconstruction of the pelvic floor and APC tissues.
A vaginal hysterectomy with uterine appendages was performed, which was accompanied by increased tissue bleeding, given the recent inflammatory process with thickening of all anatomical structures of the small pelvis and, first of all, the ligamentous apparatus of the uterus and the walls of the bladder and vagina. Total blood loss was about 200.0 mL. Duration of the operation 1 hour 15 minutes.
The postoperative period was without complications. Postoperative tissue repair was per primam. Discharged under the supervision of a family doctor with recommendations for a healthy lifestyle and hygiene measures. The general appearance of the perineum on the 10th day after the surgical intervention using the proposed method is presented in Fig. 3.
Figure 3: Appearance of the perineum on the 10th day after vaginal hysterectomy with uterine appendages.
We have successfully treated a case of complete internal GP with pinching and dysfunction of the pelvic organs. Such neglected clinical cases are rare, so we present our algorithm of actions, which may be useful to gynecologists. More often there are cases of complete internal GP with decubital ulcers, nonspecific and specific vaginitis and the development of inflammatory-trophic changes in the mucous membrane of the vagina and cervix [25]. Local antimicrobial and anti-inflammatory therapy of such cases is of paramount importance with the possibility of further surgical treatment of complete internal GP [41,42].
For local treatment, we preferred the use of Octenisept, given our clinical experience of the high effectiveness of this antiseptic in the case of nonspecific and specific vaginitis in gynecological practice (especially with resistant forms of E. coli, Staphylococcus aureus and Enterobacteriaceae - as in our case), compared to other antiseptics, which is also confirmed by the data of previous clinical studies conducted by other authors [28-31].
Control of the effectiveness of local therapy of vaginitis is valid according to microbiological studies of vaginal secretions and the level of vaginal cytokines (IL-6 and IL-8). In our study, the post-treatment levels of vaginal IL-6 (14 pg/mL) and IL-8 (77 pg/mL) correspond to a marked reduction in local inflammation. These findings are consistent with previous reports demonstrating that effective treatment of bacterial vaginosis results in significant decreases in cervical and vaginal IL-6 and IL-8 concentrations [42, 43]. Yudin MH et al. showed that inflammatory cytokines were significantly lower after successful local therapy [39]. Mtshali A. et al. confirmed short-term reductions in mucosal IL-8 during the recovery of the vaginal microbiome after metronidazole treatment [40]. In addition, octenidine-based antiseptics (such as Octenisept) have demonstrated the ability to reduce IL-6 and IL-8 in ex-vivo and in-vitro models, supporting their potential anti-inflammatory action [41].
Thus, our two-stage therapy of complete internal GP was effective, which is confirmed by the absence of complications in the patient in the postoperative period.
It is necessary to continue clinical studies on a larger number of patients with internal GP an inflammatory-trophic changes in the vagina and cervix, as well as against the background of specificand nonspecific vaginitis regarding the effectiveness of Octenisept for the prevention of purulent-inflammatory complications in the postoperative period in this group of patients.
The case of complete internal GP with pelvic hernia entrapment and pelvic organ dysfunction was successfully treated thanks to the correctly selected two-stage treatment of the patient with initial hernia reduction, local use the Octenisept, antibacterial, anti-inflammatory therapy acute pyelonephritis with subsequent performed vaginal hysterectomy by 10 steps in our modification.
Clearly Auctoresonline and particularly Psychology and Mental Health Care Journal is dedicated to improving health care services for individuals and populations. The editorial boards' ability to efficiently recognize and share the global importance of health literacy with a variety of stakeholders. Auctoresonline publishing platform can be used to facilitate of optimal client-based services and should be added to health care professionals' repertoire of evidence-based health care resources.
Journal of Clinical Cardiology and Cardiovascular Intervention The submission and review process was adequate. However I think that the publication total value should have been enlightened in early fases. Thank you for all.
Journal of Women Health Care and Issues By the present mail, I want to say thank to you and tour colleagues for facilitating my published article. Specially thank you for the peer review process, support from the editorial office. I appreciate positively the quality of your journal.
Journal of Clinical Research and Reports I would be very delighted to submit my testimonial regarding the reviewer board and the editorial office. The reviewer board were accurate and helpful regarding any modifications for my manuscript. And the editorial office were very helpful and supportive in contacting and monitoring with any update and offering help. It was my pleasure to contribute with your promising Journal and I am looking forward for more collaboration.
We would like to thank the Journal of Thoracic Disease and Cardiothoracic Surgery because of the services they provided us for our articles. The peer-review process was done in a very excellent time manner, and the opinions of the reviewers helped us to improve our manuscript further. The editorial office had an outstanding correspondence with us and guided us in many ways. During a hard time of the pandemic that is affecting every one of us tremendously, the editorial office helped us make everything easier for publishing scientific work. Hope for a more scientific relationship with your Journal.
The peer-review process which consisted high quality queries on the paper. I did answer six reviewers’ questions and comments before the paper was accepted. The support from the editorial office is excellent.
Journal of Neuroscience and Neurological Surgery. I had the experience of publishing a research article recently. The whole process was simple from submission to publication. The reviewers made specific and valuable recommendations and corrections that improved the quality of my publication. I strongly recommend this Journal.
Dr. Katarzyna Byczkowska My testimonial covering: "The peer review process is quick and effective. The support from the editorial office is very professional and friendly. Quality of the Clinical Cardiology and Cardiovascular Interventions is scientific and publishes ground-breaking research on cardiology that is useful for other professionals in the field.
Thank you most sincerely, with regard to the support you have given in relation to the reviewing process and the processing of my article entitled "Large Cell Neuroendocrine Carcinoma of The Prostate Gland: A Review and Update" for publication in your esteemed Journal, Journal of Cancer Research and Cellular Therapeutics". The editorial team has been very supportive.
Testimony of Journal of Clinical Otorhinolaryngology: work with your Reviews has been a educational and constructive experience. The editorial office were very helpful and supportive. It was a pleasure to contribute to your Journal.
Dr. Bernard Terkimbi Utoo, I am happy to publish my scientific work in Journal of Women Health Care and Issues (JWHCI). The manuscript submission was seamless and peer review process was top notch. I was amazed that 4 reviewers worked on the manuscript which made it a highly technical, standard and excellent quality paper. I appreciate the format and consideration for the APC as well as the speed of publication. It is my pleasure to continue with this scientific relationship with the esteem JWHCI.
This is an acknowledgment for peer reviewers, editorial board of Journal of Clinical Research and Reports. They show a lot of consideration for us as publishers for our research article “Evaluation of the different factors associated with side effects of COVID-19 vaccination on medical students, Mutah university, Al-Karak, Jordan”, in a very professional and easy way. This journal is one of outstanding medical journal.
Dear Hao Jiang, to Journal of Nutrition and Food Processing We greatly appreciate the efficient, professional and rapid processing of our paper by your team. If there is anything else we should do, please do not hesitate to let us know. On behalf of my co-authors, we would like to express our great appreciation to editor and reviewers.
As an author who has recently published in the journal "Brain and Neurological Disorders". I am delighted to provide a testimonial on the peer review process, editorial office support, and the overall quality of the journal. The peer review process at Brain and Neurological Disorders is rigorous and meticulous, ensuring that only high-quality, evidence-based research is published. The reviewers are experts in their fields, and their comments and suggestions were constructive and helped improve the quality of my manuscript. The review process was timely and efficient, with clear communication from the editorial office at each stage. The support from the editorial office was exceptional throughout the entire process. The editorial staff was responsive, professional, and always willing to help. They provided valuable guidance on formatting, structure, and ethical considerations, making the submission process seamless. Moreover, they kept me informed about the status of my manuscript and provided timely updates, which made the process less stressful. The journal Brain and Neurological Disorders is of the highest quality, with a strong focus on publishing cutting-edge research in the field of neurology. The articles published in this journal are well-researched, rigorously peer-reviewed, and written by experts in the field. The journal maintains high standards, ensuring that readers are provided with the most up-to-date and reliable information on brain and neurological disorders. In conclusion, I had a wonderful experience publishing in Brain and Neurological Disorders. The peer review process was thorough, the editorial office provided exceptional support, and the journal's quality is second to none. I would highly recommend this journal to any researcher working in the field of neurology and brain disorders.
Dear Agrippa Hilda, Journal of Neuroscience and Neurological Surgery, Editorial Coordinator, I trust this message finds you well. I want to extend my appreciation for considering my article for publication in your esteemed journal. I am pleased to provide a testimonial regarding the peer review process and the support received from your editorial office. The peer review process for my paper was carried out in a highly professional and thorough manner. The feedback and comments provided by the authors were constructive and very useful in improving the quality of the manuscript. This rigorous assessment process undoubtedly contributes to the high standards maintained by your journal.
International Journal of Clinical Case Reports and Reviews. I strongly recommend to consider submitting your work to this high-quality journal. The support and availability of the Editorial staff is outstanding and the review process was both efficient and rigorous.
Thank you very much for publishing my Research Article titled “Comparing Treatment Outcome Of Allergic Rhinitis Patients After Using Fluticasone Nasal Spray And Nasal Douching" in the Journal of Clinical Otorhinolaryngology. As Medical Professionals we are immensely benefited from study of various informative Articles and Papers published in this high quality Journal. I look forward to enriching my knowledge by regular study of the Journal and contribute my future work in the field of ENT through the Journal for use by the medical fraternity. The support from the Editorial office was excellent and very prompt. I also welcome the comments received from the readers of my Research Article.
Dear Erica Kelsey, Editorial Coordinator of Cancer Research and Cellular Therapeutics Our team is very satisfied with the processing of our paper by your journal. That was fast, efficient, rigorous, but without unnecessary complications. We appreciated the very short time between the submission of the paper and its publication on line on your site.
I am very glad to say that the peer review process is very successful and fast and support from the Editorial Office. Therefore, I would like to continue our scientific relationship for a long time. And I especially thank you for your kindly attention towards my article. Have a good day!
"We recently published an article entitled “Influence of beta-Cyclodextrins upon the Degradation of Carbofuran Derivatives under Alkaline Conditions" in the Journal of “Pesticides and Biofertilizers” to show that the cyclodextrins protect the carbamates increasing their half-life time in the presence of basic conditions This will be very helpful to understand carbofuran behaviour in the analytical, agro-environmental and food areas. We greatly appreciated the interaction with the editor and the editorial team; we were particularly well accompanied during the course of the revision process, since all various steps towards publication were short and without delay".
I would like to express my gratitude towards you process of article review and submission. I found this to be very fair and expedient. Your follow up has been excellent. I have many publications in national and international journal and your process has been one of the best so far. Keep up the great work.
We are grateful for this opportunity to provide a glowing recommendation to the Journal of Psychiatry and Psychotherapy. We found that the editorial team were very supportive, helpful, kept us abreast of timelines and over all very professional in nature. The peer review process was rigorous, efficient and constructive that really enhanced our article submission. The experience with this journal remains one of our best ever and we look forward to providing future submissions in the near future.
I am very pleased to serve as EBM of the journal, I hope many years of my experience in stem cells can help the journal from one way or another. As we know, stem cells hold great potential for regenerative medicine, which are mostly used to promote the repair response of diseased, dysfunctional or injured tissue using stem cells or their derivatives. I think Stem Cell Research and Therapeutics International is a great platform to publish and share the understanding towards the biology and translational or clinical application of stem cells.
I would like to give my testimony in the support I have got by the peer review process and to support the editorial office where they were of asset to support young author like me to be encouraged to publish their work in your respected journal and globalize and share knowledge across the globe. I really give my great gratitude to your journal and the peer review including the editorial office.
I am delighted to publish our manuscript entitled "A Perspective on Cocaine Induced Stroke - Its Mechanisms and Management" in the Journal of Neuroscience and Neurological Surgery. The peer review process, support from the editorial office, and quality of the journal are excellent. The manuscripts published are of high quality and of excellent scientific value. I recommend this journal very much to colleagues.
Dr.Tania Muñoz, My experience as researcher and author of a review article in The Journal Clinical Cardiology and Interventions has been very enriching and stimulating. The editorial team is excellent, performs its work with absolute responsibility and delivery. They are proactive, dynamic and receptive to all proposals. Supporting at all times the vast universe of authors who choose them as an option for publication. The team of review specialists, members of the editorial board, are brilliant professionals, with remarkable performance in medical research and scientific methodology. Together they form a frontline team that consolidates the JCCI as a magnificent option for the publication and review of high-level medical articles and broad collective interest. I am honored to be able to share my review article and open to receive all your comments.
“The peer review process of JPMHC is quick and effective. Authors are benefited by good and professional reviewers with huge experience in the field of psychology and mental health. The support from the editorial office is very professional. People to contact to are friendly and happy to help and assist any query authors might have. Quality of the Journal is scientific and publishes ground-breaking research on mental health that is useful for other professionals in the field”.
Dear editorial department: On behalf of our team, I hereby certify the reliability and superiority of the International Journal of Clinical Case Reports and Reviews in the peer review process, editorial support, and journal quality. Firstly, the peer review process of the International Journal of Clinical Case Reports and Reviews is rigorous, fair, transparent, fast, and of high quality. The editorial department invites experts from relevant fields as anonymous reviewers to review all submitted manuscripts. These experts have rich academic backgrounds and experience, and can accurately evaluate the academic quality, originality, and suitability of manuscripts. The editorial department is committed to ensuring the rigor of the peer review process, while also making every effort to ensure a fast review cycle to meet the needs of authors and the academic community. Secondly, the editorial team of the International Journal of Clinical Case Reports and Reviews is composed of a group of senior scholars and professionals with rich experience and professional knowledge in related fields. The editorial department is committed to assisting authors in improving their manuscripts, ensuring their academic accuracy, clarity, and completeness. Editors actively collaborate with authors, providing useful suggestions and feedback to promote the improvement and development of the manuscript. We believe that the support of the editorial department is one of the key factors in ensuring the quality of the journal. Finally, the International Journal of Clinical Case Reports and Reviews is renowned for its high- quality articles and strict academic standards. The editorial department is committed to publishing innovative and academically valuable research results to promote the development and progress of related fields. The International Journal of Clinical Case Reports and Reviews is reasonably priced and ensures excellent service and quality ratio, allowing authors to obtain high-level academic publishing opportunities in an affordable manner. I hereby solemnly declare that the International Journal of Clinical Case Reports and Reviews has a high level of credibility and superiority in terms of peer review process, editorial support, reasonable fees, and journal quality. Sincerely, Rui Tao.
Clinical Cardiology and Cardiovascular Interventions I testity the covering of the peer review process, support from the editorial office, and quality of the journal.
Clinical Cardiology and Cardiovascular Interventions, we deeply appreciate the interest shown in our work and its publication. It has been a true pleasure to collaborate with you. The peer review process, as well as the support provided by the editorial office, have been exceptional, and the quality of the journal is very high, which was a determining factor in our decision to publish with you.
The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews journal clinically in the future time.
Clinical Cardiology and Cardiovascular Interventions, I would like to express my sincerest gratitude for the trust placed in our team for the publication in your journal. It has been a true pleasure to collaborate with you on this project. I am pleased to inform you that both the peer review process and the attention from the editorial coordination have been excellent. Your team has worked with dedication and professionalism to ensure that your publication meets the highest standards of quality. We are confident that this collaboration will result in mutual success, and we are eager to see the fruits of this shared effort.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, I hope this message finds you well. I want to express my utmost gratitude for your excellent work and for the dedication and speed in the publication process of my article titled "Navigating Innovation: Qualitative Insights on Using Technology for Health Education in Acute Coronary Syndrome Patients." I am very satisfied with the peer review process, the support from the editorial office, and the quality of the journal. I hope we can maintain our scientific relationship in the long term.
Dear Monica Gissare, - Editorial Coordinator of Nutrition and Food Processing. ¨My testimony with you is truly professional, with a positive response regarding the follow-up of the article and its review, you took into account my qualities and the importance of the topic¨.
Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.
Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”
Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner
My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.
My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.
My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.
I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.
Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."
I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.
To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.
"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".
I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.
Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.
We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.
My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.
To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina
Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.
Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.
Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.
Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD
Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.
Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.
Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
