Evolution of Cognitive and Socio-Emotional Skills in an older Woman with Autism Spectrum Disorders and Severe Intellectual Disability Receiving Individualized Support Based on the CHIPPS Program: A Clinical Case Report

Case Report | DOI: https://doi.org/10.31579/2690-8808/256

Evolution of Cognitive and Socio-Emotional Skills in an older Woman with Autism Spectrum Disorders and Severe Intellectual Disability Receiving Individualized Support Based on the CHIPPS Program: A Clinical Case Report

  • Jean-Louis Adrien 1*
  • Célia Nézereau 1,2
  • Marion Wolff 3
  • Marie-Davia Wardi 2
  • Maria Pilar Gattegno 1,4
  • Romuald Blanc 1,5

1 Laboratory of Psychopathology and Health Processes (UR4057), Institute of Psychology, Université Paris Cité, Paris, France.

2 Office of Psychology ESPAS-Sup, 97, Avenue Charles de Gaulle, 92200 Neuilly sur Seine.

3 Espace-Tests PEPSS (Plateforme d’Évaluation, de Prototypage et de teSts d’usageS). ESTIA-TECH, 97, Allée Théodore Monod – Technopole Izarbel – 64 210 BIDART.

4 Office of Psychology ESPAS-Sup, 12, Avenue du 8 Mai 1945, 33110 Bordeaux-Le Bouscat.

5Research unit UMR 1253, iBrain, Université de Tours, INSERM Group “Autismˮ, Tours, France.

*Corresponding Author: Jean-Louis Adrien, Laboratory of Psychopathology and Health Processes (UR4057), Institute of Psychology, Université Paris Cité, Paris, France.

Citation: Jean L. Adrien, Célia Nézereau, Marion Wolff, Marie D. Wardi, Maria P. Gattegno, et al., (2025), Evolution of Cognitive and Socio-Emotional Skills in an older Woman with Autism Spectrum Disorders and Severe Intellectual Disability Receiving Individualized Support Based on the CHIPPS Program: A Clinical Case Report, J, Clinical Case Reports and Studies, 6(8); DOI:10.31579/2690-8808/256

Copyright: ©, 2025, Jean-Louis Adrien. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: 16 May 2025 | Accepted: 29 May 2025 | Published: 24 November 2025

Keywords: adults with ASD and severe ID; evolution of cognitive and socio-emotional abilities; social cognitive evaluation battery for adults (SCEB-A); cognitive and social remediation; personalized support

Abstract

Older adults with autism spectrum disorders (ASD) and severe intellectual disability (ID) require constant and regularly updated relational, social, and healthy support. This paper presents the evolution of cognitive and socio-emotional abilities in a 69-year-old female patient with this dual diagnosis (associated with epilepsy) who benefited from a personalized psycho-educative program.

The program, which includes cognitive and social remediation sessions and daily individual coaching to promote personal autonomy, was implemented daily for two years (15 hours per week). Cognitive and socio-emotional development was assessed using the Social Cognitive Evaluation Battery adapted for Adults (SCEB-A) at intervention commencement (Time 1) and completion (Time 2; 24 months).

An increase in abilities was noted in all cognitive and socio-emotional domains.

Older individuals with ASD, severe ID, and epilepsy can make progress in cognitive and socio-emotional functioning through the regular application of a psycho-educative program. However, this study is limited due to the inclusion of a single participant, and thus, the results cannot be generalized to older adults with ASD and severe ID.

1. Introduction

Autism spectrum disorder (ASD) is considered a lifelong neuro-developmental disorder, the severity of which is augmented by intellectual disability [1]; it currently represents a significant public health issue. ASD can be associated with several mental, somatic, and neurological comorbidities [2,3], including epilepsy [4], of which the median period prevalence in individuals with autism is estimated to be between 12.1% and 17.2% [5]. This co-occurring condition necessitates adapted and personalized anti-epileptic treatments [6]. Additionally, for those with multiple diagnoses, whose autism is categorized as “profound” [7,8], both psycho-educational and behavioral supports and medical treatments are required for long-term care and quality of life [9,10]. Thus, some adults—including older adults— require constant and regularly updated support in all areas of relational and social life, autonomy, and health, as highlighted by Roestorf et al. [11]. However, prior literature indicates that behavioral and educative interventions in adults with ASD have received little academic attention in comparison to children [12] despite the increased life expectancy in Western societies and the increased prevalence of ASD [13].

Several studies on aging in ASD have shown the elevated risk of cognitive and neurological disorders [14-16]. However, to our knowledge, there has been no study focused on the cognitive and adaptive evolution of aging adults with ASD, severe ID, and neurological disorders who are receiving personalized support combined with medical treatment.

While many professionals consider that these individuals can no longer learn and progress, this case report highlights the evolution of cognitive and socio-emotional abilities in a senior female patient with ASD and severe ID associated with epilepsy. The patient benefited from an individualized psycho-educative program over a period of two years.

2. Case presentation

This study concerns a 69-year-old female who had been diagnosed with “psychotic disorders, schizophrenic reactionsˮ at the age of 13 [17] and presented with epilepsy of unknown etiology at 66 years of age. Despite receiving an anti-epileptic treatment (Lactimal), the epilepsy had not yet stabilized. Since the age of 34, the patient has attended a medico-social establishment known as a Specialized Reception Home (SRH). As part of a research partnership between the SRH and a university, the patient was selected to be included in the study [18]. At the request of the patient’s legal guardian, an individualized support development program was delivered to the patient in the SRH over a period of two consecutive years from the commencement of the study. The legal guardian provided consent for the use of the retrospective data presented in this case report.

2.1 ASD and ID diagnosis process of the patient

The ASD diagnosis [19] was undertaken using the PDD-MRS (Pervasive Development Disorders-Mental Retardation), validated in a French clinical population [20]. The patient’s score was 13 (cut-off = 10). The CARS (Childhood Autism Rating Scale) [21] was used to determine the severity of the autistic symptomatology; the CARS score of 44.5 (cut-off = 30) indicated severe autism.

Given her very low cognitive level, the participant could not be assessed using standardized intelligence tests. As such, the level of ID was determined through a clinical assessment undertaken by clinicians who were well-acquainted with the patient and were able to rate the ability level in the following two domains: Social and Personal Autonomy and Communication [18]. The ID of the patient was classified as severe.

2.2 Assessment of cognitive and socio-emotional development

2.1.1 The assessment of cognitive and socio-emotional development was undertaken using the Socio-Emotional and Cognitive Battery (SCEB, [22]). Initially used specifically for children with ASD and other neurodevelopment disorders [23], the SCEB was recently adapted for use with adults (SCEB-A) whose development levels are below that of a 24-month-old [18]. The SCEB-A’s psychometric proprieties were recently shown of evidence [24]. This tool assesses 16 domains, which are classified into two main areas: cognitive (7 domains) and socio-emotional (9 domains). Each of these ability domains comprises several items hierarchized into four levels of development that correspond to age bands: level 1 = 4-8 months; level 2 = 8-12 months; level 3 = 12-18 months; and level 4 = 18-24 months. Level 0 was indicated when no items were passed at level 1. The patient’s cognitive and socio-emotional development assessment was performed by a psychologist trained in using SCEB-A (the second author of this paper).

2.1.2. Rating of SCEB-A items from adult behaviors

In the standardized rating of SCEB-A [24], each behavior item was rated 0 when the adult did not perform the behavior, 1 when the adult performed it with gestural support and/or after a demonstration from the examiner, and 2 when the adult performed it alone with no assistance or demonstration. Two types of development profiles were determined from these ratings: “consolidatedˮ (determined for each of the 16 domains as being the highest level for which all items were rated 2) and “achievedˮ (determined for each of these same domains as being the highest level in which at least one item had a score of 1). The difference or lag between the consolidated (e.g., level 1) and achieved (e.g., level 3) levels indicated that the individual had good acquisition and mastery of the behaviors expected for level 1 but had yet to master those of levels 2 and 3, despite being able to perform some of them with support, assistance, or demonstration. Levels 2 and 3 are considered to be consolidated when the individual exhibits all behaviors for the items without assistance or demonstration.

2.3 Program of individualized coaching: the CHIPPS program

Applied by a coach under the supervision of a psychologist [26], the psycho-educative intervention known as Coaching Home Intervention Progress Profession School® (CHIPPS) is an effective intervention program [27] designed to take place in naturalistic environments [28]. It is based on both behavioral and developmental psychological models [29] and includes all relevant recommendations from France’s High Authority for Health (HAS) relative to the support and autonomy of adults with ASD, by which it has been cited [30,31].

2.4 Content and description of the cognitive and socio-emotional remediation session

The remediation session comprised several learning exercises, which were chosen in alignment with the patient’s development profiles for the achieved and consolidated levels, as obtained during the first SCEB-A evaluation [26]. In each of the 16 domains, all behaviors that were not achieved (score 0) or only partially successful (score 1) were identified, and the proposed learning exercises corresponded to these behavioral items. For instance, during the SCEB-A evaluation, the patient took the styling brush and tried to style the doll’s hair but could not. The accompanying support consisted of helping the patient use the brush correctly to groom the doll by demonstrating the action and/or using the gestural aid of taking the patient’s hand in such a way as to invite them to style the doll's hair. Once this gesture had been acquired, the patient was mobilized to style their own hair.

2.5 Data analysis

Increasing levels of consolidated development across all areas should show evidence of adult progress. To assess this progress, a Single Case Research (SCR) procedure [32,33] was implemented for the analysis of individual effects; this procedure is particularly suitable for small-sample studies. The method has been successfully applied in previous studies, particularly to validate the effects of different support programs for children with ASD [28]. The principle is based on the measurement of “Nonoverlapping data” collected in two distinct phases—Time 1 Level and Time 2 Level—which were combined to give the trend for the latter. This allows the undesirable positive trend of the first phase to be controlled. Firstly, the Nonoverlap of All Pairs (NAP) was calculated; this corresponded to the percentage of nonoverlapping points and was calculated by comparing the points of the second phase with those of the first phase. The higher the percentage, the less overlap there was between points, indicating an effect attributable to the program (0% to 30% = weak effect; 31% to 84% = moderate effect; ≥ 85% = significant effect). Secondly, the SCR procedure uses the Tau-U method, which can be defined as a derivation of Kendall’s Tau and the Mann-Whitney U non-parametric test (searching for differences between groups of data), as it also refers to the “S” statistics sampling distribution. The Tau-U calculator program indicates Tau-U, Tau-U Standard Deviation (SD), the Z test result, and its p-value.

2.6 Results

2.6.1 Cognitive area

Figure 1 reports the patient’s achieved and consolidated development level score profiles at Times 1 and 2 for the cognitive area. We noted an increase in achieved development level scores for two domains: “Schemata of relation to objects” and “Object permanence.” Consolidated level scores increased in six domains—with the exception of the Means-Ends domain—and particularly in the domains of “Spatial relations” (an increase of four levels) and “Schemata of relation to objects” (an increase of three levels) (Table 1). While the slight increase in the mean achieved development level was not significant (mean differences = 0.29), the mean consolidated development level increased significantly (mean differences = 2) (Table 2).

Figure 1: Profiles of the achieved and consolidated development levels at Times 1 and 2 for the cognitive domains: Self-Image (SI); Symbolic Play (SP); Object Relation Schemata (Sch); Operational Causality (OC); Means-End (ME); Spatial Relations (SR); and Object Permanence (OP).

Individual effects

.AchievedConsolidated
 LT1LT2LT2-LT1LT1LT2LT2-LT1
SI330022
SP330022
Sch341033
OC330132
ME330220
SR440044
OP231121
Mean3.003.290.290.572.572.00
SD0.580.490.490.790.791.29

Table 1: Achieved and consolidated development level scores for cognitive domains (SI, …) at Times 1 (LT1) and 2 (LT2); means and values of differences in means between Times 1 and 2 (LT1-LT2).

Cognitive AreaTaunovlapSDTauZP
Achieved0.3380.2261.0840.278
Consolidated0.9570.31942.8740.004

Table 2: Results for Nonoverlap of All Pairs (NAP), Tau-U, Tau-U Standard Deviation (SD), Z test, and p-value

For the achieved development levels, the NAP rate was 62%, which corresponded to a moderate support effect; this effect was not significant. However, for the consolidated development levels, the NAP rate was 96%. As such, the effect of the CHIPPS program was shown to be efficient.

2.6.2 Socio-emotional area

Figure 2 represents the patient’s achieved and consolidated development levels profiles at Times 1 and 2 for the socio-emotional area. The evolution of the achieved development levels was noted in the only domain that was not achieved at the maximal level score (Vocal Imitation). Meanwhile, the consolidated levels of all nine domains increased (Table 3), particularly in Receptive Language (an increase of three developmental levels). Thus, while the slight increase in the mean achieved levels was not significant (mean differences = 0.73), the mean consolidated levels increased significantly (mean differences = 1.56) (Table 4).

Figure 2: Profiles of achieved and consolidated development levels at Times 1 and 2 for the socio-emotional domains: Receptive Language (RL); Vocal Imitation (VI); Gestural Imitation (GI); Affective Relation (AR); Emotional [removed]E); Behavior Regulation (BR); Social Interaction (SI); Joint Attention (JA); Expressive Language (EL).

Individual effects

.AchievedConsolidated
 LT1LT2LT1-LT2LT1LT2LT1-LT2
RL440033
VI440121
GI242022
AR440022
EE440011
BR440121
SI440022
JA440121
EL440231
Mean3.784.000.220.562.111.56
SD0.670.000.670.730.600.73

Table 3: Achieved and consolidated development level scores for socio-emotional domains (RL, …) at Times 1 (LT1) and 2 (LT2); means and values of the differences between means at Times 1 and 2 (LT1-LT2).

Socio-Emotional AreaTaunovlapSDTauZp
Achieved0.2000.2790.3970.691
Consolidated0.74510.2802.5160.012

Table 4: Results for: Nonoverlap of All Pairs (NAP), Tau-U, Tau-U Standard Deviation (SD), Z test, p-value

Effects similar to those of the cognitive area were observed for the socio-emotional area, with a significant effect on NAP data at 93%. Therefore, the CHIPPS program is considered to be efficient during the consolidation phases.

3. Discussion

This case report focused on the evolution of cognitive and socio-emotional abilities in a senior female who benefited from a two-year individualized support program. The increase in consolidated development levels indicates that the patient was able to learn different behaviors in all domains, including the cognitive domains of “Spatial relations” and “Schemata of relation to objects” and the socio-emotional domain of “Receptive language,” attesting to the mastery of higher developmental levels. The notable evolution in these areas demonstrates the patient learning to manipulate objects, such as fork and spoon for eating for example, and better understand others’ words during social interactions [34].

4. Conclusion

Aging does not prevent autistic adults with severe IDs from making progress. Although all development levels concerned behavioral acquisitions between 12 and 24 months of age and were minimal—highlighting the patient’s severe developmental delay—the progress in abilities identified in the patient may nevertheless be considered remarkable, despite the lack of generalizability, and showcase evidence of the possibilities in learning and cognitive and communicative evolution in severely handicapped adults [34].

Acknowledgements

We thank the patient, a senior female adult with autism and severe intellectual disability and her sister. Moreover, we thank all the members of her medico-social services team who have a convention partnership with Université Paris Cité.

We thank the Foundation Perce-Neige for its logistic and financial support.

Funding

Funds from Fondation Perce-Neige (Number H03R4057 - P5 Psycho - EA4057 – LPPS and from Faculty “Societies and Humanities” of the Université Paris Cité (Budget Restreint, Impact Optimal » ATRIUM S&H). 

Author Contributions Statement

Management of Medico-Social Service: JLA, CN and RB. Personal autonomy and behaviours observation assessments: CN and MDW. Developmental and quantitative clinical, developmental and diagnostic data collection: CN and MDW. Study design: JLA, CN, MPG, RB. Quantitative and qualitative data analysis: MW, JLA, CN, MDW, MPG and RB; Writing: JLA, CN, MW, MDW, MPG and RB.

All the authors have read and approved this final manuscript.

Availability of data and materials

The data used and analysed during this study are available from the corresponding author on reasonable request.

Ethics Statement

An information and consent form were given to the participant’s legal guardian. The study was carried out in accordance with official laws and standards of ethics, biomedical and clinical research in France. It received agreement from the research ethics committee of the University Paris Cité (N° 2021-42).

Conflict of interest

The authors declare that the submitted work was carried out in the absence of any personal, professional or financial relationships and so, does not have any conflict of interest.

References

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Dr Maria Regina Penchyna Nieto

Dear Dr. Jessica Magne, Editorial Coordinator 0f Clinical Cardiology and Cardiovascular Interventions, The review process for the article “The Handling of Anti-aggregants and Anticoagulants in the Oncologic Heart Patient Submitted to Surgery” was extremely rigorous and detailed. From the initial submission to the final acceptance, the editorial team at the “Journal of Clinical Cardiology and Cardiovascular Interventions” demonstrated a high level of professionalism and dedication. The reviewers provided constructive and detailed feedback, which was essential for improving the quality of our work. Communication was always clear and efficient, ensuring that all our questions were promptly addressed. The quality of the “Journal of Clinical Cardiology and Cardiovascular Interventions” is undeniable. It is a peer-reviewed, open-access publication dedicated exclusively to disseminating high-quality research in the field of clinical cardiology and cardiovascular interventions. The journal's impact factor is currently under evaluation, and it is indexed in reputable databases, which further reinforces its credibility and relevance in the scientific field. I highly recommend this journal to researchers looking for a reputable platform to publish their studies.

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Dr Marcelo Flavio Gomes Jardim Filho

Dear Editorial Coordinator of the Journal of Nutrition and Food Processing! "I would like to thank the Journal of Nutrition and Food Processing for including and publishing my article. The peer review process was very quick, movement and precise. The Editorial Board has done an extremely conscientious job with much help, valuable comments and advices. I find the journal very valuable from a professional point of view, thank you very much for allowing me to be part of it and I would like to participate in the future!”

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Zsuzsanna Bene

Dealing with The Journal of Neurology and Neurological Surgery was very smooth and comprehensive. The office staff took time to address my needs and the response from editors and the office was prompt and fair. I certainly hope to publish with this journal again.Their professionalism is apparent and more than satisfactory. Susan Weiner

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Dr Susan Weiner

My Testimonial Covering as fellowing: Lin-Show Chin. The peer reviewers process is quick and effective, the supports from editorial office is excellent, the quality of journal is high. I would like to collabroate with Internatioanl journal of Clinical Case Reports and Reviews.

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Lin-Show Chin

My experience publishing in Psychology and Mental Health Care was exceptional. The peer review process was rigorous and constructive, with reviewers providing valuable insights that helped enhance the quality of our work. The editorial team was highly supportive and responsive, making the submission process smooth and efficient. The journal's commitment to high standards and academic rigor makes it a respected platform for quality research. I am grateful for the opportunity to publish in such a reputable journal.

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Sonila Qirko

My experience publishing in International Journal of Clinical Case Reports and Reviews was exceptional. I Come forth to Provide a Testimonial Covering the Peer Review Process and the editorial office for the Professional and Impartial Evaluation of the Manuscript.

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Luiz Sellmann

I would like to offer my testimony in the support. I have received through the peer review process and support the editorial office where they are to support young authors like me, encourage them to publish their work in your esteemed journals, and globalize and share knowledge globally. I really appreciate your journal, peer review, and editorial office.

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Zhao Jia

Dear Agrippa Hilda- Editorial Coordinator of Journal of Neuroscience and Neurological Surgery, "The peer review process was very quick and of high quality, which can also be seen in the articles in the journal. The collaboration with the editorial office was very good."

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Thomas Urban

I would like to express my sincere gratitude for the support and efficiency provided by the editorial office throughout the publication process of my article, “Delayed Vulvar Metastases from Rectal Carcinoma: A Case Report.” I greatly appreciate the assistance and guidance I received from your team, which made the entire process smooth and efficient. The peer review process was thorough and constructive, contributing to the overall quality of the final article. I am very grateful for the high level of professionalism and commitment shown by the editorial staff, and I look forward to maintaining a long-term collaboration with the International Journal of Clinical Case Reports and Reviews.

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Cristina Berriozabal

To Dear Erin Aust, I would like to express my heartfelt appreciation for the opportunity to have my work published in this esteemed journal. The entire publication process was smooth and well-organized, and I am extremely satisfied with the final result. The Editorial Team demonstrated the utmost professionalism, providing prompt and insightful feedback throughout the review process. Their clear communication and constructive suggestions were invaluable in enhancing my manuscript, and their meticulous attention to detail and dedication to quality are truly commendable. Additionally, the support from the Editorial Office was exceptional. From the initial submission to the final publication, I was guided through every step of the process with great care and professionalism. The team's responsiveness and assistance made the entire experience both easy and stress-free. I am also deeply impressed by the quality and reputation of the journal. It is an honor to have my research featured in such a respected publication, and I am confident that it will make a meaningful contribution to the field.

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Dr Tewodros Kassahun Tarekegn

"I am grateful for the opportunity of contributing to [International Journal of Clinical Case Reports and Reviews] and for the rigorous review process that enhances the quality of research published in your esteemed journal. I sincerely appreciate the time and effort of your team who have dedicatedly helped me in improvising changes and modifying my manuscript. The insightful comments and constructive feedback provided have been invaluable in refining and strengthening my work".

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Dr Shweta Tiwari

I thank the ‘Journal of Clinical Research and Reports’ for accepting this article for publication. This is a rigorously peer reviewed journal which is on all major global scientific data bases. I note the review process was prompt, thorough and professionally critical. It gave us an insight into a number of important scientific/statistical issues. The review prompted us to review the relevant literature again and look at the limitations of the study. The peer reviewers were open, clear in the instructions and the editorial team was very prompt in their communication. This journal certainly publishes quality research articles. I would recommend the journal for any future publications.

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Dr Farooq Wandroo

Dear Jessica Magne, with gratitude for the joint work. Fast process of receiving and processing the submitted scientific materials in “Clinical Cardiology and Cardiovascular Interventions”. High level of competence of the editors with clear and correct recommendations and ideas for enriching the article.

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Dr Anyuta Ivanova

We found the peer review process quick and positive in its input. The support from the editorial officer has been very agile, always with the intention of improving the article and taking into account our subsequent corrections.

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Dr David Vinyes

My article, titled 'No Way Out of the Smartphone Epidemic Without Considering the Insights of Brain Research,' has been republished in the International Journal of Clinical Case Reports and Reviews. The review process was seamless and professional, with the editors being both friendly and supportive. I am deeply grateful for their efforts.

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Gertraud Teuchert-Noodt

To Dear Erin Aust – Editorial Coordinator of Journal of General Medicine and Clinical Practice! I declare that I am absolutely satisfied with your work carried out with great competence in following the manuscript during the various stages from its receipt, during the revision process to the final acceptance for publication. Thank Prof. Elvira Farina

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Dr Elvira Farina

Dear Jessica, and the super professional team of the ‘Clinical Cardiology and Cardiovascular Interventions’ I am sincerely grateful to the coordinated work of the journal team for the no problem with the submission of my manuscript: “Cardiometabolic Disorders in A Pregnant Woman with Severe Preeclampsia on the Background of Morbid Obesity (Case Report).” The review process by 5 experts was fast, and the comments were professional, which made it more specific and academic, and the process of publication and presentation of the article was excellent. I recommend that my colleagues publish articles in this journal, and I am interested in further scientific cooperation. Sincerely and best wishes, Dr. Oleg Golyanovskiy.

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Dr Oleg Golyanovski

Dear Ashley Rosa, Editorial Coordinator of the journal - Psychology and Mental Health Care. " The process of obtaining publication of my article in the Psychology and Mental Health Journal was positive in all areas. The peer review process resulted in a number of valuable comments, the editorial process was collaborative and timely, and the quality of this journal has been quickly noticed, resulting in alternative journals contacting me to publish with them." Warm regards, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. I appreciate the journal (JCCI) editorial office support, the entire team leads were always ready to help, not only on technical front but also on thorough process. Also, I should thank dear reviewers’ attention to detail and creative approach to teach me and bring new insights by their comments. Surely, more discussions and introduction of other hemodynamic devices would provide better prevention and management of shock states. Your efforts and dedication in presenting educational materials in this journal are commendable. Best wishes from, Farahnaz Fallahian.

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Dr Farahnaz Fallahian

Dear Maria Emerson, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. I am delighted to have published our manuscript, "Acute Colonic Pseudo-Obstruction (ACPO): A rare but serious complication following caesarean section." I want to thank the editorial team, especially Maria Emerson, for their prompt review of the manuscript, quick responses to queries, and overall support. Yours sincerely Dr. Victor Olagundoye.

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Dr Victor Olagundoye

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. Many thanks for publishing this manuscript after I lost confidence the editors were most helpful, more than other journals Best wishes from, Susan Anne Smith, PhD. Australian Breastfeeding Association.

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Dr Susan Anne Smith

Dear Agrippa Hilda, Editorial Coordinator, Journal of Neuroscience and Neurological Surgery. The entire process including article submission, review, revision, and publication was extremely easy. The journal editor was prompt and helpful, and the reviewers contributed to the quality of the paper. Thank you so much! Eric Nussbaum, MD

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Dr Eric S Nussbaum

Dr Hala Al Shaikh This is to acknowledge that the peer review process for the article ’ A Novel Gnrh1 Gene Mutation in Four Omani Male Siblings, Presentation and Management ’ sent to the International Journal of Clinical Case Reports and Reviews was quick and smooth. The editorial office was prompt with easy communication.

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Hala Al Shaikh

Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.

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Dr Rakhi Mishra

Dear Jessica Magne, Editorial Coordinator, Clinical Cardiology and Cardiovascular Interventions, Auctores Publishing LLC. The peer review process of the journal of Clinical Cardiology and Cardiovascular Interventions was excellent and fast, as was the support of the editorial office and the quality of the journal. Kind regards Walter F. Riesen Prof. Dr. Dr. h.c. Walter F. Riesen.

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Dr Walter F Riesen

Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.

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Dr Jelle Lettinga

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora

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Dariusz Ziora

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.

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Dr Ravi Shrivastava

Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.

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Dr Aline Tollet

Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.

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Dr Chiara Giuseppina Beccaluva

Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti

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Dr Claudio Ligresti

Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.

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Dr Matteo Bonori

I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.

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Edouard Kujawski

Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell

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Dr Andriy Sinelnyk

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.

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Dr Meng-JouLe

Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed

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Mahmoud Kamal Moustafa Ahmed

Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.

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Dr Elena Salvatore

Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal

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Christoph Maurer

Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.

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Baciulescu Laura

Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.

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Dr Mamoun Magzoub