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case report | DOI: https://doi.org/10.31579/2693-2156/153
Associated Professor of General Surgery, Fellowship of Liver Transplant and Hepatopancreatobiliary Surgery, Isfahan University of Medical Sciences.
*Corresponding Author: Behnam Sanei, Associated Professor of General Surgery, Fellowship of Liver Transplant and Hepatopancreatobiliary Surgery, Isfahan University of Medical Sciences.
Citation: Behnam Sanei, (2025), Challenging Biliary Reconstruction: A Case of Hepaticojejunostomy in Neurofibromatosis, J Thoracic Disease and Cardiothoracic Surgery, 6(6); DOI:10.31579/2693-2156/153
Copyright: © 2025, Behnam Sanei. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Received: 17 October 2025 | Accepted: 29 October 2025 | Published: 06 November 2025
Keywords: sinus of valsalva aneurysm; aorto-right atrial fistula; sinusoplasty
A Neurofibromatosis type 1 (NF1) is a genetic disorder, caused by peripheral nerve sheath tumors in the skin or nervous system. Its prevalance is 1 in 2600 to 3000 individuls, but only 5-25% of these patients may appear intra-abdominal manifestations, which makes it a rare medical condition. This case discusses an uncommon presentation of visceral NF1 in a 75-year-old patient with cutaneous lesions of NF1, who was admitted with right upper quadrant pain and jaundice to our hospital. Preoperative imaging studies showed a dilated and tortous common bile duct, filled with multiple stones. Because of prior unsuccesful endoscopic retrograde cholangiopancreatography (ERCP) procedures, elective choledechotomy was applied for her. The main challenge of this case was finding an area without presence of neurofibroma lesions in the small intestine for anastomosis to prevent postoperative complications, such as leakage. The other consideration for finding a suitable area was probability of obstruction of the lumen, due to growth of these lesions. This case, highlights the importance of management of patients with gastrointestinal manifestations of neurofibromatosis type 1, requiring abdominal surgical intervention.
Neurofibromatosis type 1 (NF1), or von Recklinghausen, is an autosomal dominant disorder known as peripheral nerve sheath tumors in the skin or nervous system [1]. Main clinical manifestations are cutaneous neurofibromas, café-au-lait spots, axillary and inguinal freckling, and hamartomas or Lisch nodules of the iris [2]. Diagnosis is based on these clinical features and symptoms [3].
The prevalence of NF1 is approximately 1 in 2600 to 3000 individuals. However, neoplastic intra-abdominal manifestations, may appear only in 5-25% of NF1 patients. According to the rarity of intra-abdominal lesion of NF1 and non-specific symptoms, compared to cutaneous type, has made the diagnosis and treatment approach complicated [3,4]. In previous studies, involvement of the liver, colon, and small intestine have been reported in patients who were suffered from intra-abdominal lesions [5–7]. Non-specific symptoms are the main characteristic of gastrointestinal NF1, which is recognized by abdominal pain, obstruction, and jaundice [8].
Due to the complexity of the situation that arose during surgery, this case is noteworthy. The major challenge of this procedure was locating a region of the intestine free of neurofibroma in order to guarantee ideal anastomosis, reduce leakage, and prevent other possible problems.
This case, describes a 75-year-old female, known case of von Recklinghausen (with café-au-lait spots and neurofibromatosis lesions on her body) who presented with right upper quadrant (RUQ) pain and jaundice. The patient did not mention any symptoms of gastrointestinal neurofibroma, such as constipation, obstruction, or abdominal mass. Past medical history of hypertension or diabetes mellitus was not reported. She had undergone appendectomy and hernia repairing surgery in recent years. Her gallbladder had been removed 8 years ago, followed by three endoscopic retrograde cholangiopancreatography (ERCP) procedures due to common bile duct (CBD) stones, with the most recent occurring 5 years ago. Despite these interventions, she continued to experience abdominal pain, indicative of choledocholithiasis.
Pre-operative:
Imaging studies, such as sonography and magnetic resonance cholangiopancreatography (MRCP), were performed as part of the preoperative evaluation for diagnosis and ruling out other medical conditions, such as malignancy. These revealed a significantly dilated and tortuous CBD, with a maximum diameter of 30 mm, filled with stones, and significant ectasia of the intrahepatic biliary ducts (Figure 1).
Figure 1: MRCP demonstrating dilation of CBD and presence of stones.
Initial laboratory tests revealed white blood cell count of 3820/µL, hemoglobin of 12.4 g/dL, platelet count of 137000/µL, AST level of 84, ALT level of 95, ALP 839, PT of 13.2 seconds, and PTT of 39.6 seconds. Tumor markers were negative.
Given these findings and the previous unsuccessful ERCP procedures, the decision was made to perform an elective choledochotomy. Due to presence of cholangitis, hydration and antibiotic therapy were commenced. Pre-operative evaluation was done and her ejection fraction (EF) was calculated 50-55% by echocardiography as ordered.
During operation:
An appropriate surface was achieved by doing a midline incision. Adhesion bands were observed during surgical exploration due to
previous surgeries, necessitating meticulous enterolysis for improved access to liver hilum. Choledochotomy was applied as soon as the surgical site was cleared.
The CBD was explored and exposed carefully with great care that was taken to minimize injury to crucial tissues. Biliary sludge and many stones of various sizes (maximum size was 30 mm) were removed, and the CBD was irrigated. After confirming the absence of stones, Roux-en-Y choledochojejunostomy was performed for the patient.
The main challenge during surgery was identifying a suitable segment of the small intestine devoid of lesions for performing anastomosis on jejunal wall, due to the complication introduced by widespread neurofibromas (Figure 2).
Figure 2: a: Widespread cutaneous neurofibroma lesions on the trunk b: Visceral neurofibromas in many segments of small intestine and liver, detected during surgery.
In order to reduce the chance of difficulties and guarantee a clear area for the anastomosis, the surgeon explored around mentioned lesions. After dividing the jejunum with a linear cartridge stapler and bringing the Roux limb near the hepatic duct, a side-to-side anastomosis was created between the common hepatic duct and jejunal limb to make future ERCP(s) possible, if required.
In the next step, enteroenterostomy was applied. The presence of neurofibroma restricted this surgical step, as the surgeon had to find a clear site for optimal anastomosis to ensure that the least complications such as leakage or obstruction would occur postoperatively.
Post-operative management:
The patient’s recovery was stable and uneventful without any special medical problem. She was also monitored for possible complications, such as bile leakage, but none were reported. Per oral (PO) regimen was started the following day, and on the 5th day after operation, the patient discharged in good general health condition and no complications.
Intra-abdominal neurofibromas are extremely rare, which only 5-25% of patients with NF1 may be suffered [4]. Ait Ali et al, reported a patient with intestinal obstruction and solitary neurofibroma of small bowel, which did not experience any clinical symptoms of gastrointestinal neurofibroma similarly to our case [5].
Al-Harake et al, described a case of a patient with peptic ulcer disease and hiatal hernia, who presented with epigastric abdominal pain. The patient was diagnosed with sever gastritis. Distention of stomach, duodenum, jejunum and ileum, caused by intestinal intussusception due to an ileal tumor was obvious in CT scan image. Final investigations revealed an isolated intestinal neurofibroma with no associated syndromes in ileum [9].
In another study, Fujisawa et al, reported a 26-year-old man, who underwent a cholecystectomy prodecure. During the operation and imaging studies, he was known as a case of intra-abdominal plexiform neurofibromatosis, including periportal, mesentric, and gastrointestinal tract involvement [10].
In contrast to the skin lesions seen in NF1, the diagnosis of intestinal neurofibroma is difficult, because patients may experience severe complications, including intestinal obstruction, ischemic bowel, or perforation. Additionally, patients with gastrointestinal NF1 may suffer from medical conditions requiring intra-abdominal surgical intervention, such as Choledochotomy. The presence of neurofibromas in the abdomen, especially in the small intestine, makes the surgical procedure complicated and obscured for performing delicate intervention [5].
The treatment of choice for common bile duct (CBD) stones is endoscopic retrograde cholangiopancreatography (ERCP), which allows physicians to explore and clear the CBD from stones. In patients with multiple large stones, ERCP is not feasible and open surgical techniques are more effective, as same as our case [11-13].
This case emphasizes the challenges, encountered during the surgery of a patient with intra-abdominal neurofibroma, which made the operation process difficult, especially due to combination with adhesions from prior surgeries. Another phenomenon that surgeon had to consider was obstruction of the lumen, as consequence of growth or thickening of neurofibromatosis lesions in the anastomsosis site. The patient’s preferred method of treatment was choledochotomy. This surgical intervention required careful planning with delicate anastomosis, which is important to minimize complications, such as bile leakage postoperatively [14].
The appearance of neurofibroma, posed difficulties by obstructing the surgical site and made it complex for surgeon to find appropriate space for anastomosis, in counter of small bowel region without presence of neurofibroma. An additional factor that surgeon had to take notice was the possibility for growth of these lesions at the anastomosis site, which consequently may cause intestinal obstruction.
This case describes the challenges of treating a patient with intra-abdominal neurofibromas. Patients with generalized skin lesions of NF1, may require surgical intervention in the abdomen and gastrointestinal tract. During surgery visceral lesions can be detected, which complicates the surgery procedure and probable anastomosis. In this case, despite the challenges faced during choledochotomy procedure, the patient’s surgery was quite successful without no major complication, which emphasizes the importance of identifying a lesion-free segment of the intestine for anastomosis in cases of intra-abdominal NF1.
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Dear Erin Aust, Editorial Coordinator, Journal of General Medicine and Clinical Practice. We are pleased to share our experience with the “Journal of General Medicine and Clinical Practice”, following the successful publication of our article. The peer review process was thorough and constructive, helping to improve the clarity and quality of the manuscript. We are especially thankful to Ms. Erin Aust, the Editorial Coordinator, for her prompt communication and continuous support throughout the process. Her professionalism ensured a smooth and efficient publication experience. The journal upholds high editorial standards, and we highly recommend it to fellow researchers seeking a credible platform for their work. Best wishes By, Dr. Rakhi Mishra.
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Dear Ashley Rosa, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews, Auctores Publishing LLC. Thank you for publishing our article, Exploring Clozapine's Efficacy in Managing Aggression: A Multiple Single-Case Study in Forensic Psychiatry in the international journal of clinical case reports and reviews. We found the peer review process very professional and efficient. The comments were constructive, and the whole process was efficient. On behalf of the co-authors, I would like to thank you for publishing this article. With regards, Dr. Jelle R. Lettinga.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, I would like to express my deep admiration for the exceptional professionalism demonstrated by your journal. I am thoroughly impressed by the speed of the editorial process, the substantive and insightful reviews, and the meticulous preparation of the manuscript for publication. Additionally, I greatly appreciate the courteous and immediate responses from your editorial office to all my inquiries. Best Regards, Dariusz Ziora
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation, Auctores Publishing LLC, We would like to thank the editorial team for the smooth and high-quality communication leading up to the publication of our article in the Journal of Neurodegeneration and Neurorehabilitation. The reviewers have extensive knowledge in the field, and their relevant questions helped to add value to our publication. Kind regards, Dr. Ravi Shrivastava.
Dear Clarissa Eric, Editorial Coordinator, Journal of Clinical Case Reports and Studies, Auctores Publishing LLC, USA Office: +1-(302)-520-2644. I would like to express my sincere appreciation for the efficient and professional handling of my case report by the ‘Journal of Clinical Case Reports and Studies’. The peer review process was not only fast but also highly constructive—the reviewers’ comments were clear, relevant, and greatly helped me improve the quality and clarity of my manuscript. I also received excellent support from the editorial office throughout the process. Communication was smooth and timely, and I felt well guided at every stage, from submission to publication. The overall quality and rigor of the journal are truly commendable. I am pleased to have published my work with Journal of Clinical Case Reports and Studies, and I look forward to future opportunities for collaboration. Sincerely, Aline Tollet, UCLouvain.
Dear Ms. Mayra Duenas, Editorial Coordinator, International Journal of Clinical Case Reports and Reviews. “The International Journal of Clinical Case Reports and Reviews represented the “ideal house” to share with the research community a first experience with the use of the Simeox device for speech rehabilitation. High scientific reputation and attractive website communication were first determinants for the selection of this Journal, and the following submission process exceeded expectations: fast but highly professional peer review, great support by the editorial office, elegant graphic layout. Exactly what a dynamic research team - also composed by allied professionals - needs!" From, Chiara Beccaluva, PT - Italy.
Dear Maria Emerson, Editorial Coordinator, we have deeply appreciated the professionalism demonstrated by the International Journal of Clinical Case Reports and Reviews. The reviewers have extensive knowledge of our field and have been very efficient and fast in supporting the process. I am really looking forward to further collaboration. Thanks. Best regards, Dr. Claudio Ligresti
Dear Chrystine Mejia, Editorial Coordinator, Journal of Neurodegeneration and Neurorehabilitation. “The peer review process was efficient and constructive, and the editorial office provided excellent communication and support throughout. The journal ensures scientific rigor and high editorial standards, while also offering a smooth and timely publication process. We sincerely appreciate the work of the editorial team in facilitating the dissemination of innovative approaches such as the Bonori Method.” Best regards, Dr. Matteo Bonori.
I recommend without hesitation submitting relevant papers on medical decision making to the International Journal of Clinical Case Reports and Reviews. I am very grateful to the editorial staff. Maria Emerson was a pleasure to communicate with. The time from submission to publication was an extremely short 3 weeks. The editorial staff submitted the paper to three reviewers. Two of the reviewers commented positively on the value of publishing the paper. The editorial staff quickly recognized the third reviewer’s comments as an unjust attempt to reject the paper. I revised the paper as recommended by the first two reviewers.
Dear Maria Emerson, Editorial Coordinator, Journal of Clinical Research and Reports. Thank you for publishing our case report: "Clinical Case of Effective Fetal Stem Cells Treatment in a Patient with Autism Spectrum Disorder" within the "Journal of Clinical Research and Reports" being submitted by the team of EmCell doctors from Kyiv, Ukraine. We much appreciate a professional and transparent peer-review process from Auctores. All research Doctors are so grateful to your Editorial Office and Auctores Publishing support! I amiably wish our article publication maintained a top quality of your International Scientific Journal. My best wishes for a prosperity of the Journal of Clinical Research and Reports. Hope our scientific relationship and cooperation will remain long lasting. Thank you very much indeed. Kind regards, Dr. Andriy Sinelnyk Cell Therapy Center EmCell
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. It was truly a rewarding experience to work with the journal “Clinical Cardiology and Cardiovascular Interventions”. The peer review process was insightful and encouraging, helping us refine our work to a higher standard. The editorial office offered exceptional support with prompt and thoughtful communication. I highly value the journal’s role in promoting scientific advancement and am honored to be part of it. Best regards, Meng-Jou Lee, MD, Department of Anesthesiology, National Taiwan University Hospital.
Dear Editorial Team, Journal-Clinical Cardiology and Cardiovascular Interventions, “Publishing my article with Clinical Cardiology and Cardiovascular Interventions has been a highly positive experience. The peer-review process was rigorous yet supportive, offering valuable feedback that strengthened my work. The editorial team demonstrated exceptional professionalism, prompt communication, and a genuine commitment to maintaining the highest scientific standards. I am very pleased with the publication quality and proud to be associated with such a reputable journal.” Warm regards, Dr. Mahmoud Kamal Moustafa Ahmed
Dear Maria Emerson, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews’, I appreciate the opportunity to publish my article with your journal. The editorial office provided clear communication during the submission and review process, and I found the overall experience professional and constructive. Best regards, Elena Salvatore.
Dear Mayra Duenas, Editorial Coordinator of ‘International Journal of Clinical Case Reports and Reviews Herewith I confirm an optimal peer review process and a great support of the editorial office of the present journal
Dear Editorial Team, Clinical Cardiology and Cardiovascular Interventions. I am really grateful for the peers review; their feedback gave me the opportunity to reflect on the message and impact of my work and to ameliorate the article. The editors did a great job in addition by encouraging me to continue with the process of publishing.
Dear Cecilia Lilly, Editorial Coordinator, Endocrinology and Disorders, Thank you so much for your quick response regarding reviewing and all process till publishing our manuscript entitled: Prevalence of Pre-Diabetes and its Associated Risk Factors Among Nile College Students, Sudan. Best regards, Dr Mamoun Magzoub.
